I-bu-rG Phosphoramidite CAS 147201-04-5 Purity ≥98.5% (HPLC) Purity ≥98.5% (31P-NMR) RNA Phosphoramidites

Short Description:

Chemical Name: I-bu-rG Phosphoramidite

Synonyms: DMT-2′O-TBDMS-rG(ib) Phosphoramidite

CAS: 147201-04-5

Purity: ≥98.5% (HPLC)

Purity: ≥98.5% (31P-NMR)

Appearance: White or Off-White Powder

RNA Phosphoramidites; Modified Nucleotides

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Product Detail

Product Tags

RNA Phosphoramidites:

rU Phosphoramidite	CAS 118362-03-1
Ac-rC Phosphoramidite	CAS 121058-88-6
Bz-rA Phosphoramidite	CAS 104992-55-4
I-bu-rG Phosphoramidite	CAS 147201-04-5
2'-OMe-A(Bz) Phosphoramidite	CAS 110782-31-5

147201-04-5 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of I-bu-rG Phosphoramidite (DMT-2′O-TBDMS-rG(ib) Phosphoramidite) (CAS: 147201-04-5) with high quality. I-bu-rG Phosphoramidite is a modified building block commonly used in the solid-phase synthesis of RNA oligonucleotides.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase I-bu-rG Phosphoramidite or other products, please contact us by e-mail: alvin@ruifuchem.com

147201-04-5 - Chemical Properties:

Chemical Name	I-bu-rG Phosphoramidite
Synonyms	rG(ibu) Phosphoramidite; DMT-2′O-TBDMS-rG(ib) Phosphoramidite; 2'-TBDMS-rG(N-ibu)Phosphoramidite; 2'-TBDMS-ibu-G-CE-Phosphoramidite; 5'-O-DMT-2'-TBDMS-rG(N-iBu)-3'-CEDPA; N-(2-methyl-1-oxopropyl)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-guanosine; 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; 5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-N-isobutyrylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(tert-butyldimethylsilyloxy)-5-(2-isobutyramido-6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite
Stock Status	In Stock
CAS Number	147201-04-5
Molecular Formula	C50H68N7O9PSi
Molecular Weight	970.18 g/mol
Storage Temperature	Sealed in Dry, Store in Freezer, Under -20℃ Upon Receipt of the Product
Shipping Conditions	Shipped Under Ambient Temperature For Short Term
COA & MSDS	Available
Origin of Product	Shanghai, China
Product Categories	RNA Phosphoramidites; Modified Nucleotides
Caution	Not For Human or Veterinary Use. For Research Use Only.
Brand	Ruifu Chemical

147201-04-5 - Specifications:

Items	Specifications	Results
Appearance	White or Off-White Powder	White Powder
Solution Clarity Test	Clear	Clear
UV Spectrum	200~350 nm, the maximum and minimum absorption wavelengths differ from the standard spectrum by +2nm	Conforms
Water Content	≤0.30% (Karl Fischer)	Conforms
Residual Solvent Content	≤3.00% (GC)	Conforms
Single Impurity	≤0.50% (HPLC)	Conforms
Purity / Analysis Method	≥98.5% (HPLC)	98.6%
Purity / Analysis Method	≥98.5% (31P-NMR)	Conforms
1H NMR Spectrum	Conforms to Structure	Conforms
LC-MS	Conforms to Structure	Conforms
Conclusion	The product has been tested and complies with the given specifications

147201-04-5 - Package/Storage/Shipping:

Package: 1g/10g/50g/100g/1kg/10kg/bulk. Amber glass screw cap vial or white plastic bottle.
Storage Condition: Keep the container tightly closed. Sealed in dry, store in freezer, under -20℃, under nitrogen. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

147201-04-5 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

147201-04-5 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

147201-04-5 - Risk and Safety:

WGK Germany	3
HS Code	2934 9990.01

147201-04-5 - Introduction:

I-bu-rG Phosphoramidite (DMT-2′O-TBDMS-rG(ib) Phosphoramidite) (CAS: 147201-04-5) is a modified building block commonly used in the solid-phase synthesis of RNA oligonucleotides. It is a guanosine nucleoside modified with a tert-butyldimethylsilyl (TBDMS) group protecting the 3'-OH group and an isobutyryl (ibu) group protecting the N2 position. The phosphoramidite group is attached to the 2'-OH position of the nucleoside.
I-bu-rG Phosphoramidite is used in the synthesis of oligonucleotides and nucleoside analogs for a variety of applications in biochemistry, molecular biology, and biotechnology.

147201-04-5 - Scientific Research Applications:

I-bu-rG Phosphoramidite (DMT-2′O-TBDMS-rG(ib) Phosphoramidite) (CAS: 147201-04-5) is used in the synthesis of nucleoside analogs and DNA/RNA oligonucleotides for a variety of applications in biochemistry, molecular biology, and biotechnology. It is used in the synthesis of modified DNA/RNA molecules for use in gene editing, gene therapy, and gene regulation. I-bu-rG Phosphoramidite is also used in the synthesis of modified nucleosides for use in drug discovery and development, as well as in the development of diagnostic assays.

147201-04-5 - Mechanism of Action:

I-bu-rG Phosphoramidite (DMT-2′O-TBDMS-rG(ib) Phosphoramidite) (CAS: 147201-04-5) is a phosphoramidite monomer that is used in the synthesis of nucleoside analogs and DNA/RNA oligonucleotides. I-bu-rG Phosphoramidite is incorporated into the oligonucleotide chain during synthesis, and the 2-bromo-6-amino-4-nitrophenyl group at the 5’ position is used to modify the structure of the oligonucleotide. This modification can be used to alter the activity of the oligonucleotide or to target specific sequences.

147201-04-5 - Biochemical and Physiological Effects:

I-bu-rG Phosphoramidite (DMT-2′O-TBDMS-rG(ib) Phosphoramidite) (CAS: 147201-04-5) has been shown to have a variety of biochemical and physiological effects. It is used in the synthesis of modified DNA/RNA molecules for use in gene editing, gene therapy, and gene regulation. It has also been used in the synthesis of modified nucleosides for use in drug discovery and development, as well as in the development of diagnostic assays.

147201-04-5 - Advantages and Limitations for Lab Experiments:

I-bu-rG Phosphoramidite (DMT-2′O-TBDMS-rG(ib) Phosphoramidite) (CAS: 147201-04-5) has several advantages and limitations for lab experiments. One advantage is that it is relatively easy to synthesize and can be used to modify the structure of DNA/RNA oligonucleotides. Additionally, it is inexpensive and can be used in a variety of applications. However, I-bu-rG Phosphoramidite has some limitations. For example, it is not as stable as other phosphoramidite monomers, and it can be difficult to deprotect.

147201-04-5 - Future Directions:

There are several future directions for the use of I-bu-rG Phosphoramidite. It could be used to develop new nucleoside analogs for use in drug discovery and development. Additionally, I-bu-rG Phosphoramidite could be used to create modified DNA/RNA molecules for use in gene editing, gene therapy, and gene regulation. Finally, I-bu-rG Phosphoramidite could be used to develop new diagnostic assays for a variety of diseases. I-bu-rG phosphoramidite include expanding its therapeutic applications further, particularly in gene therapy and targeted drug delivery.